Carla Minaudo

Autores/as

Carla Minaudo Hospital Británico de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina

Palabras clave:

angiosarcoma cutáneo, angiosarcoma de la piel de la cabeza, angiosarcoma posradioterapia, angiosarcoma asociado a linfedema, síndrome de Stewart-Treves

Resumen

El angiosarcoma (AS) cutáneo es una neoplasia maligna poco frecuente (1,6% de los sarcomas cutáneos) y uno de los tumores de la piel más agresivos y de peor pronóstico. Tiene un origen celular mixto: vascular hemático y linfático. Casi la totalidad de los casos de angiosarcomas cutáneos (ASc) tienen tres patrones de presentación: el angiosarcoma idiopático de la piel de la cabeza (ASpc), el angiosarcoma asociado a linfedema crónico (ASlc) y el angiosarcoma secundario a radioterapia (ASrt). Asimismo, pueden observarse en la piel (con menor frecuencia), AS sobre otros territorios o patologías predisponentes y AS de localización visceral, en los que el compromiso cutáneo puede ser el primer signo para el diagnóstico.Aunque la rareza de esta patología y de sus variantes dificultan esta-blecer un tratamiento unificado, se ha observado una mejor sobrevi-da en los pacientes con terapia multimodal, que combinacirugía con quimioterapia y radioterapia.Entre las novedades terapéuticas se mencionan, por un lado, el uso creci-ente de betabloqueantes como adyuvantes para reducir el volumen tumoral. Por otro lado, la perfusión del miembro aislado se propone como alternativa a la amputación en el síndrome de Stewart-Treves (ST-T).

Biografía del autor/a

Carla Minaudo, Hospital Británico de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina

Médica Asistente del Servicio de Dermatología

Citas

I. Requena C, Rubio L, Lavernia J, Machado I, et ál. Immunohistochemical and Fluorescence In Situ Hybridization Analysis of MYC in a Series of 17 Cutaneous Angiosarcomas: A Single-Center Study. Am J Dermatopathol 2018;40:349-354.

II. Morales Gordillo V, Armario Hita JC, Fernández Vozmediano JM. Angiosarcomas cutáneos. Med Cutan Iber Lat Am 2008;36:146-151.

III. Koch M, Nielsen GP, Yoon SS. Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangiopericytomas. J Surg Oncol 2008;97:321-329.

IV. Marcon I, Collini P, Casanova M, Meazza C, et ál. Cutaneous angiosarcoma in a patient with xeroderma pigmentosum. Pediatr Hematol Oncol 2004;21:23-26.

V. Martín P, Pulpillo A, Cabrera R, Conejo-Mir J. Abdominal wall angiosarcoma in a patient with drug-induced immunosuppression following renal transplantation. Actas Dermosifiliogr 2016;107:162-163.

VI. Oskrochi AY, Razi BK, Stebbing CJ, Crane AJ. Angiosarcoma and dialysis-related arteriovenous fistulae: a comprehensive review. Eur J Vasc Endovasc Surg 2016;51:127-133.

VII. Albores-Saavedra J, Schwartz AM, Henson D, Kostum L. Cutaneous angiosarcoma. Analysis of 434 cases from the Surveillance, Epidemiology, and End Results Program, 1973-2007. Ann Diagn Pathol 2011;15:93-97.

VIII. Pawlik TM, Paulino AF, McGinn CJ, Baker LH, et ál. Cutaneous angiosarcoma of the scalp: a multidisciplinary approach. Cancer 2003;98:1716-1726.

IX. Rouhani P, Fletcher CD, Devesa SS, Toro JR. Cutaneous soft tissue sarcoma incidence patterns in the US: an analysis of 12,114 cases. Cancer 2008;113:616-627.

X. Shustef E, Kazlouskaya V, Prieto VG, Ivan D, et ál. Cutaneous angiosarcoma: a current update. J Clin Pathol 2017;70:917-925.

XI. Styring E, Fernebro J, Jönsson PE, Ehinger A, et ál. Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall. Breast Cancer Res Treat 2010;122:883-887.

XII. Patel SH, Hayden RE, Hinni ML, Wong WW, et ál. Angiosarcoma of the scalp and face: the Mayo Clinic experience. JAMAOtolaryngol Head Neck Surg 2015;141:335-340.

XIII. Singla S, Papavasiliou P, Powers B, Gaughan J, et ál. Challenges in the treatment of angiosarcoma: a single institution experience. Am J Surg 2014;208:254-259.

XIV. West JG, Weitzel JN, Tao ML, Carpenter M, et ál. BRCA mutations and the risk of angiosarcoma after breast cancer treatment. Clin Breast Cancer 2008;8:533-537.

XV. Penel N, Grosjean J, Robin YM, Vanseymortier L, et ál.Frequency of certain established risk factors in soft tissue sarcomas in adults: a prospective descriptive study of 658 cases. Sarcoma 2008. doi:10.1155/2008/459386, [consulta: enero de 2018].

XVI. Ishida Y, Otsuka A, Kabashima K. Cutaneous angiosarcoma: update on biology and latest treatment. Curr Opin Oncol 2018; 30:107-112.

XVII. Wagner JM, Vinod R, Menter DG, Sood AK. Endothelial cell malignancies: new insights from the laboratory and clinic. NPJ Precision Oncology 2017;1:11; doi:10.1038/s41698-017-0013-2.

XVIII. Requena L, Sangueza OP. Cutaneous vascular proliferations. Part III. Malignant neoplasms, other cutaneous neoplasms with significant vascular component, and disorders erroneously considered as vascular neoplasms. J Am Acad Dermatol1998;38:176-178.

XIX. Neglia V, Harris P, Mobilia M, Abeldaño A, et ál. Angiosarcoma de cuero cabelludo. Casos clínicos y revisión de la literatura. Dermatol Argent 1997;3:42-47.

XX. North PE, Hull CH, Kincannon J.Neoplasias y proliferaciones seudoneoplásicas vasculares. En: Bolognia J, Jorizzo J, Rapini RP. Dermatología. Elsevier, Madrid, 2004:1833-1835.

XXI. Chiu CS, Lin CY, Kuo TT, Kuan YZ, et ál. Malignant cutaneous tumors in the scalp: study of demographiccharacteristics and histologic distributions of 398 taiwanese patients. J Am Acad Dermatol 2007;56:448-452.

XXII. Marini MA, Casas JG, Baldrich MA. Angiosarcoma de la piel de la cabeza. Arch Argent Dermatol 2003;53:207-212.

XXIII. Magnin PH, Schroh RG, Carrera GF. Angiosarcoma de la piel de la cabeza. Rev Arg Derm 1987;78:30-31.

XXIV. Dossett LA, Harrington M, Wayne Cruse C, González RJ. Cutaneous angiosarcoma. Curr Probl Cancer 2015;39:258-263.

XV. Sturgis EM, Potter BO. Sarcomas of the head and neck region. Curr Opin Oncol 2003;15:239-252.

XVI. Huang X, Sun S. Primary eyelid angiosarcoma in a Chinese patient. Int J Clin Exp Pathol 2015;8:8636-8638.

XVII. Aguila LI, Sánchez JL. Angiosarcoma of the face resembling rhinophyma. J Am Acad Dermatol 2003;49:530-531.

XVIII. Murray S, Simmons I, James C. Cutaneous angiosarcoma of the face and scalp presenting as alopecia. Australas J Dermatol2003;44:273-276.

XXIX. Wen S, Zhang W, Yang Y, Sun J. Angiosarcoma of the scalp and face associated with Kasabach-Merritt syndrome and disseminated intravascular coagulation. Indian J Dermatol Venereol Leprol 2016;82:96-97.

XXX. LeBoit PE, Burg G, Weedon D, Sarasain A. World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours. IARC Press: Lyon 2006; 236-243.

XXXI. Asgari MM, Cockerell CJ, Weitzul S. The head-tilt maneuver: a clinical aid in recognizing head and neck angiosarcomas. Arch Dermatol 2007;143:75-77.

XXXII. Sholl LM, Barletta JA, Hornick JL. Radiation-associated neoplasia: clinical, pathological and genomic correlates. Histopathology 2017;70:70-80.

XXXIII. Toll A. Cutaneous angiosarcoma: the importance of clinical suspicion. Actas Dermosifiliogr 2017;108:394.

XXXIV. Ford SJ, Almond LM, Gronchi A. An Update on Non-extremity Soft Tissue Sarcomas. Clin Oncol (R Coll Radiol) 2017;29:516-527.

XXXV. Wen-Hui Chen, Bai-Yao Wu, Wei-Ming Wang. Distinction of a postradiation atypical vascular lesion from cutaneous angiosarcoma in a patient with a history of breast cancer. Dermatologica Sinica 2014;32:187-188.

XXXVI. Gengler C, Coindre JM, Leroux A, Trassard M, et ál. Vascular proliferations of the skin after radiation therapy for breast cancer: clinicopathologic analysis of a series in favor of a benign process: a study from the French Sarcoma Group. Cancer 2007;109:1584-1598.

XXXVII. Combemale P, Hetu J, Aubriot-Lorton MH, Jeudy G, et ál.Cutaneous lesions in sporadic angiosarcomas of the breast: a misleading presentation. Eur J Dermatol 2016;26:287-289.

XXXVIII. Berebichez-Fridman R, Deutsch YE, Joyal TM, Olvera PM, et ál.Stewart-Treves Syndrome: A Case Report and Review of the Literature. Case Rep Oncol 2016;9:205-211.

XXXIX. Parra R LS, Marini MA. Angiosarcoma asociado a linfedema crónico. En: Marini MA, Casas JG, Saponaro AE. Tumores cutáneos malignos infrecuentes: sarcomas. Alfaomega, Buenos Aires, 2012:129-144.

XL. Cui L, Zhang J, Zhang X, Chang H, et ál. Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature. Int J Clin Exp Pathol2015;8:11108-11115.

XLI. Lee R, Saardi KM, Schwartz RA. Lymphedema-related angiogenic tumors and other malignancies. Clin Dermatol2014;32:616-620.

XLII. Shin JY, Roh SG, Lee NH, Yang KM. Predisposing factors for poor prognosis of angiosarcoma of the scalp and face: Systematic review and meta-analysis. Head Neck 2017;39:380-386.

XLIII. Deyrup AT, McKenney JK, Tighiouart M, Folpe AL, et ál. Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. Am J Surg Pathol 2008;32:72-77.

XLIV. Alan S, Aktas H, Ersoy ÖF, Aktümen A, et ál. Stewart Treves syndrome in a woman with mastectomy. J Clin Diagn Res2016;10(2):WD01-WD02.

XLV. Peterson CB, Beauregard S. Radiation-induced breast angiosarcoma: case report and clinical approach. J Cutan Med Surg 2016;20:304-307.

XLVI. Nashan D. Cutaneous sarcomas. Journal Der Deutschen Dermatologischen Gesellschaft 2017; doi:10.1111/ddg.13249.

XLVII. Requena C, Sendra E, Llombart B, Sanmartín O, et ál.Angiosarcoma cutáneo: estudio clínico-patológico de 16 casos. Actas Dermosifiliogr 2017;108:457-465.

XLVIII. Lahat G, Dhuka AR, Hallevi H, Xiao L, et ál. Angiosarcoma: clinical and molecular insights. Ann Surg 2010;251:1098-1106.

XLIX. Trofymenko O, Curiel-Lewandrowski C. Surgical treatment associated with improved survival in patients with cutaneous angiosarcoma. J Eur Acad Dermatol Venereol 2018;32:e29-e31.

L. Li GZ, Fairweather M, Wang J, Orgill DP, et ál. Cutaneous radiation-associated breast angiosarcoma radicality of surgery impacts survival. Ann Surg 2017; 65:814-820.

LI. Young RJ, Woll PJ. Anti-angiogenic therapies for the treatment angiosarcoma: a clinical update. Memo 2017;10:190-193.

LII. Huis In ‘t Veld EA, Grünhagen DJ, Verhoef C, Smith HG, et ál. Isolated limb perfusion for locally advanced angiosarcoma in extremities: A multi-centre study. Eur J Cancer 2017;85:114-121.

LIII. Minaudo C, Marini MA. Tumores vasculares. En: Marini MA, Casas JG, Saponaro AE. Tumores cutáneos malignos infrecuentes: sarcomas. Alfaomega, Buenos Aires, 2012:105-128.

LIV. Sindhu S, Gimber LH, Cranmer L, McBride A. Angiosarcoma treated successfully with anti-PD-1 therapy – a case report. JImmunother Cancer 2017;5:58.

LV. Pasquier E, André N, Street J, Chougule A, et ál. Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study. EBioMedicine 2016;6:87-95.

LVI. Chow W, Amaya CN, Rains S, Chow M, et ál. Growth attenuation of cutaneous angiosarcoma with propranolol-mediated β-blockade. JAMA Dermatol 2015;151:1226-1229.