Síndrome multiorgánico autoinmune paraneoplásico desencadenado por radioterapia

Macarena Sánchez Costantini; Diego Martín Loriente; Carmen Tatiana Alfaro; Patricia Silvia Della Giovanna

doi:10.47196/da.v30i2.2582

Authors

Macarena Sánchez Costantini Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina
Diego Martín Loriente Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina
Carmen Tatiana Alfaro Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina
Patricia Silvia Della Giovanna Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v30i2.2582

Keywords:

paraneoplastic autoimmune multiorgan syndrome, paraneoplastic pemphigus, breast cancer, radiotherapy

Abstract

Paraneoplastic autoimmune multiorgan syndrome, formerly called paraneoplastic pemphigus is an infrequent type of pemphigus that affects skin, semimucosal, mucosal and internal organs. It is potentially fatal. Occurs in the context of neoplasms which can precede, be concomitant with or develop after the dermatological condition. Breast cancer represent a very rare cause. It has been described as caused or exacerbated by chemotherapy and radiotherapy.

We present a case of a 59 years old woman with a history of breast cancer that developed one month after completing radiotherapy treatment a condition of clinical, histologic and immunologic features compatible with paraneoplastic pemphigus with good response to treatment and favourable evolution.

Author Biographies

Macarena Sánchez Costantini, Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina

Physician, Chief Resident of Dermatology

Diego Martín Loriente, Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina

Staff Physician, Dermatology Specialist

Carmen Tatiana Alfaro, Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina

Pathologist, Pathological Anatomy Service

Patricia Silvia Della Giovanna, Professor Alejandro Posadas National Hospital, El Palomar, Province of Buenos Aires, Argentina

Physician, Head of the Dermatology Service

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