Pemphigoid gestationis

Authors

  • María Albán Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina
  • Sabrina Meik Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina
  • María Inés Hernández Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina
  • Yanina Berberian Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina
  • Vicenta Neglia Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v31i1.2565

Keywords:

pemphigoid gestationis, herpes gestationis, rash and pregnancy

Abstract

Pemphigoid gestationis is a rare autoimmune blistering disease. It occurs in the second or third trimester and during the puerperium. It may be associated with fetal risk due to placental failure. Clinically it presents with a polymorphous and pruritic rash that starts in the periumbilical region with subsequent formation of tense blisters and variable extension. Diagnosis is based on clinical findings, histopathology and direct immunofluorescence of healthy perilesional skin.  We present the case of a 37-year-old female patient who developed pemphigoid gestationis in the third trimester of pregnancy.

Author Biographies

María Albán, Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina

Medical Student, Dermatology Specialist Course, University of Buenos Aires

Sabrina Meik, Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina

Staff Physician

María Inés Hernández, Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina

Staff Physician

Yanina Berberian, Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina

Physician, Chief Resident

Vicenta Neglia, Dr. Cosme Argerich General Acute Hospital, City of Buenos Aires, Argentina

Head of the Dermatology Unit

References

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V. Yang A, Uslenhake E, Murell D. Pemphigoid gestationis and intravenous immunoglobulin therapy. Int J Womens Dermatol. 2018;4:166-169.

VI. Lobato-Berezo A, Fernández M, Moreno J, Pujol R. Penfigoide gestacional simulando un eritema multiforme con afectación mucosa. Actas Dermo-Sifiliog. 2019;110:696-697.

VII. Sood S, Yeung J, Mufti A. Biologic therapy for refractory pemphigoid gestationis: an evidence- based systematic review. JAAD Int. 2023;13:134-136.

VIII. Al-Saif F, Elisa A, Al-Homidy A, Al-Ageel A, et ál. Retrospective analysis of pemphigoid gestationis in 32 saudi patients clinic pathological features and a literature review. J Reprod Immunol. 2016;116:42-45.

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Published

2025-04-04

Issue

Vol. 31 No. 1 (2025): January-April

Section

Clinical Cases

License

Copyright (c) 2024 on behalf of the authors. Reproduction rights: Argentine Society of Dermatology

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