Diagnóstico de las enfermedades ampollares subepidérmicas autoinmunes

Mónica Beatriz Di Milia; Marcelo Gabriel Label; Luciana Cabral Campana

doi:10.47196/da.v30i1.2516

Authors

Mónica Beatriz Di Milia Ramos Mejía Hospital, Autonomous City of Buenos Aires, Argentina
Marcelo Gabriel Label Ramos Mejía Hospital, Autonomous City of Buenos Aires, Argentina
Luciana Cabral Campana Ramos Mejía Hospital, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v30i1.2516

Keywords:

subepidermal autoimmune bullous disease, diagnostic, blisters

Abstract

There is a large clinical, histological and immunological overlap between subepidermal autoimmune bullous diseases (SABD). The molecular knowledge of the dermoepidermal junction is basic to understanding this group of pathologies. Immunological studies are absolutely essential for the diagnosis of this heterogeneous group of diseases. In spite of everything, immunological studies have only increased the feeling of immense ignorance that people have when delving into SABD. In practice, clinically suspected cases of one type of SABD correspond immunologically to another. We are going to try to clarify some concepts and give the diagnostic keys.

Author Biographies

Mónica Beatriz Di Milia, Ramos Mejía Hospital, Autonomous City of Buenos Aires, Argentina

Physician of the Autoimmune Blistering Diseases Sector, Dermatology Division

Marcelo Gabriel Label, Ramos Mejía Hospital, Autonomous City of Buenos Aires, Argentina

Emeritus Physician, Consultant of the Dermatology Division, Dermatology Division

Luciana Cabral Campana, Ramos Mejía Hospital, Autonomous City of Buenos Aires, Argentina

Staff Physician in charge of the Autoimmune Blistering Diseases Sector, Dermatology Division

References

I. Forero O, Candiz ME, Olivares L. Abordajes fisiopatogénicos y diagnósticos. En: Dermatosis ampollares autoinmunes. Haga su diagnóstico. 1° Ed. Ciudad Autónoma de Buenos Aires: Journal 2022;1-51.

II. Hashimoto T, Qian H, Ishii N, Nakama T, Tateishi C, Tsuruta D, Li X. Classification and antigen molecules of autoimmune bullous diseases. Biomolecules. 2023;13:703.

III. Label MG. Técnicas de inmunofluorescencia directas e indirectas aplicadas a la dermatología. Tesis de Doctorado, Facultad de Medicina, Universidad de Buenos Aires; 1989.

IV. Forero OL, Candiz ME, Fernández-Bussy R, Dickson C, et ál. Guías de manejo de penfigoide ampollar 2021 [en línea]. Publicación de la Sociedad Argentina de Dermatología, 2021;1. Disponible en <https://sad.org.ar/wpcontent/uploads/2021/09/Guias-de-manejo-de-PA.pdf> [Consultado febrero 2024].

V. El-Domyati M, Abdel-Wahab H, Ahmad H. Immunohistochemical localization of basement membrane laminin 5 and collagen IV in adult linear IgA disease. Int J Dermatol 2015;54:922-928.

VI. Yenamandra VK, Bhari N, Ray SB, Sreenivas V, et ál. Diagnosis of inherited epidermolysis bullous in resource-limited settings: immunohistochemistry revisited. Dermatology. 2017;233:326-332.

VII. Candiz ME, Forero O, Olivares L, Muñoz del Toro M, et ál. Diagnóstico serológico de patologías ampollares autoinmunitarias. Dermatol Argent. 2018;24:177-184.

VIII. Harrell J, Rubio XB, Nielson C, Hsu S, et ál. Advances in the diagnosis of autoimmune bullous dermatoses. Clinics in Dermatology. 2019;37:692-712.

IX. Holtsche M, Beek N, Künstner A, Busch H, et ál. Diagnostic value and practicability of serration pattern analysis by direct immunofluorescence microscopy in pemphigoid diseases. Acta Derm Venereol. 2021;101:adv00410.

X. Koga H, Prost-Squarcioni C, Iwata H, Jonkman MlF, et ál. Epidermolysis bullous acquisita: The 2019 Update. Front Med. 2019;5:362.

XI. Sernicola A, Russo I, Saponeri A, Alaibac M. et ál. Biochip detection of BP180 autoantibodies in blister fluid for the serodiagnosis of bullous pemphigoid. A pilot study. Medicine 2019;98:e14514.

XII. Patel MP, Jones VA, Murray TN, Amber KT. A review comparing International guidelines for the management of bullous pemphigoid, pemphigoid gestationis, mucous membrane pemphigoid, and epidermolysis bullous acquisita. Am J Clin Dermatol. 2020;21:557-565.

XIII. Shih YC, Yuan H, Shen J, Zheng J, et ál. BP230 IgE autoantibodies in topical-steroid-resistant bullous pemphigoid. J Dermatol 2021;48:1372-1380.

XIV. Madera-Guzmán M, Hirigoity MB, Kim H, Alduncin J, et ál. Penfigoide gestacional. Rev Argent Dermatol 2020;(101):4.

XV. Alarcón PD, Alarcón AF, Alarcón CR, Aravena FF, et ál. Penfigoide del embarazo: a propósito de un caso clínico y revisión de la literatura. Rev Chil Dermatol. 2011;27:62-70.

XVI. Uceda ME, Guillén M. Dermatosis del embarazo. A propósito de un caso. Semergen 2014;40:e8-13.

XVII. De Diego MC, Eimer L, Suar L, Marchese ML, et ál. Liquen plano con ampollas: piense en liquen plano penfigoide. Dermatol Argent. 2013;19:286-288.

XVIII. Hübner F, Langan EA, Recke A. Lichen planus phemphigoides: from lichenoid inflammation to autoantibody-mediated blistering. Front Immunol. 2019;10:1389.

XIX. Kuperman-Wilder L, Bordón MP, Cilio AM, Cabral-Campana L, et ál. Penfigoide de las mucosas a lo largo de los años en nuestro Servicio. Dermatol Argent. 2021;27:155-160.

XX. Rashid H, Lamberts A, Borradori L, Alberti-Violetti S, et ál. European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the European Academy of Dermatology and Venereology. Part 1. J Eur Acad Dermatol Venereol. 2021;35:1750-1764.

XXI. Schmidt E, Rashid H, Marzano AV, Lamberts A, et ál. European guidelines (S3) on diagnosis and management of mucous membrane pemphigoid, initiated by the Europan Academy of Dermatology and Venereology. Part II. J Eur Acad Dermatol Venereol. 2021;35: 1926-1948.

XXII. Du G, Patzelt S, van Beek N, Schmidt E. Mucous membrane pemphigoid. Autoimmun Rev. 2022;21:103036.

XXIII. Kamaguchi M, Iwata H. The diagnosis and blistering mechanisms of mucous membrane pemphigoid. Front Immunol. 2019;10:1-8.

XXIV. Pérez DL, Forero OL, Olivares L Candiz ME. Dermatosis ampollares subepidérmicas neutrofílicas. Dermatol Argent. 2016;22:171-182.

XXV. González-Naranjo AL, Vázquez-Duque GM, Restrepo-Escobar M. Enfermedad ampollosa en el lupus eritematoso sistémico. Iatreia [en línea] 2012;25:229-239 [Consultado febrero 2024]. ISSN:0121-0793. Disponible en: https://www.redalyc.org/articulo.oa?id=180523371006.

XXVI. Ginzburg K, Forero O, Candiz ME, Maronna E, et ál. Penfigoide anti-p200: ¿enfermedad poco frecuente o subdiagnosticada? Dermatol Argent. 2022;28:25-29.

XXVII. Holtsche MM, Goletz S, Zillikens D. Anti-p200-pemphigoid. Hautarzt 2019;70:271-276.

XXVIII. Kridin K, Ahmed AR. Anti-p200 pemphigoid: a systematic review. Front Immunol. 2019;10:2466.

XXIX. Merenzon S, Di Milia MB, Cabral-Campana L, Dickson C, et ál. Estudio retrospectivo de 10 pacientes adultos con enfermedad ampollar autoinmune por inmunoglobulina A línea. Dermatol Argent. 2023;29:113-119.

XXX. Antiga E, Maglie R, Quintarelli L, Verdelli A, et ál. Dermatitis herpetiforme: novel perspectives. Front Immunol. 2019;10:1290.