Acute generalized exanthematous pustulosis due to unusual drugs
DOI:
https://doi.org/10.47196/da.v29i2.2367Keywords:
exanthematous pustulosis, drug-induced skin reaction, griseofulvin, pseudoephedrineAbstract
Acute generalized exanthematous pustulosis (AGEP) is considered a rare drug-induced skin reaction. It manifests clinically as an acute rash associated with multiple non-follicular pustules and fever. Clinical, laboratory and histopathological criteria are used for its diagnosis and its treatment primarily involves withdrawal of the causative medicine associated or not with topical or systemic corticosteroid therapy. AGEP usually has favorable prognosis but in rare cases it may lead to severe systemic compromise. We report two patients with AGEP attributed to pseudoephedrine and griseofulvin are presented, drugs that were not reported in the Argentine literature and few reports worldwide, who had favorable evolution after treatment.
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