Reactive granulomatous dermatitis: interstitial granulomatous dermatitis and palisade neutrophilic granulomatous dermatitis

Authors

  • Julia Manfrin British Hospital, Autonomous City of Buenos Aires, Argentina
  • Carla Minaudo British Hospital, Autonomous City of Buenos Aires, Argentina
  • Félix Vigovich British Hospital, Autonomous City of Buenos Aires, Argentina
  • Sandra García Hospital Posadas, Province of Buenos Aires, Argentina.
  • José Gabriel Casas† British Hospital, Autonomous City of Buenos Aires, Argentina
  • Alberto Saponaro British Hospital, Autonomous City of Buenos Aires, Argentina
  • Gabriel Noriega British Hospital, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v28i2.2284

Keywords:

reactive granulomatous dermatitis, interstitial granulomatous dermatitis, palisade neutrophilic granulomatous dermatitis

Abstract

Palisade neutrophilic granulomatous dermatitis and interstitial granulomatous dermatitis belong to the reactive granulomatous dermatitis group. They are uncommon conditions that may have overlapping clinical and histopathological findings, even in the same patient. It is currently considered as a spectrum that begins as palisade granulomatous dermatitis and then evolves to interstitial granulomatous dermatitis.

They are called “reactive” due to their association in up to 75% of cases with systemic pathologies. The most common is rheumatoid arthritis, followed by lupus, drugs, neoplasms, and infections. In the remaining 25% no associated pathologies are found.

They usually respond to topical or systemic steroids or treatment of the underlying disease. In some cases, spontaneous resolution is observed.

We present three patients with reactive granulomatous dermatitis, studied to rule out associated systemic pathologies.

Author Biographies

Julia Manfrin, British Hospital, Autonomous City of Buenos Aires, Argentina

Former Resident of the Dermatology Service

Carla Minaudo, British Hospital, Autonomous City of Buenos Aires, Argentina

Dermatologist at the Dermatology Service

Félix Vigovich, British Hospital, Autonomous City of Buenos Aires, Argentina

Pathologist, Pathology Service

Sandra García, Hospital Posadas, Province of Buenos Aires, Argentina.

Medical Pathologist, Former Head of the Pathology Service, Hospital Posadas. Private practice

José Gabriel Casas†, British Hospital, Autonomous City of Buenos Aires, Argentina

Consulting Physician, Dermatology Service

Alberto Saponaro, British Hospital, Autonomous City of Buenos Aires, Argentina

Dermatologist, Former Head of the Dermatology Service

Gabriel Noriega, British Hospital, Autonomous City of Buenos Aires, Argentina

Dermatologist, Head of Dermatology Service

References

I. Rosenbach M, English J. Reactive granulomatous dermatitis. A review of palisaded neutrophilic and granulomatous dermatitis, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, and a proposed reclassification. Dermatol Clin 2015;33:373-387.

II. Kern M, Shiver MB, Addis KM, Gardner JM. Palisaded neutrophilic and granulomatous dermatitis/interstitial granulomatous dermatitis overlap: a striking clinical and histologic presentation with “burning rope sign” and subsequent mirror-image contralateral recurrence. Am J Dermatopathol. 2017; 39:e141-e146.

III. Chu P, Connolly K, LeBoit PE. The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol. 1994;130:1278-1283.

IV. Peroni A, Colato C, Schena D, Gisondi P, et ál. Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. Br J Dermatol. 2012;166:775-783.

V. Imadojemu S, Rosenbach M. Advances in inflammatory granulomatous skin diseases. Dermatol Clin. 2019;37:49-64.

VI. Misago N, Shinoda Y, Tago M, Narisawa Y. Palisaded neutrophilic granulomatous dermatitis with leukocytoclastic vasculitis in a patient without any underlying systemic disease detected to date. J Cutan Pathol. 2010;37:1092-1097.

VII. Alavi A, Sajic D, Cerci FB, Ghazarian D, et ál. Neutrophilic dermatoses: an update. Am J Clin Dermatol. 2014;15:413-423.

VIII. Rodríguez Caruncho C, Bielsa Marsol I. Dermatitis granulomatosa intersticial. Semin Fund Esp Reumatol. 2010;11:64-69.

IX. Lozano-Masdemont B, Baniandrés-Rodriguez O, Parra-Blanco V, Suárez-Fernández R. Dermatitis granulomatosa como manifestación cutánea de trastornos hematológicos: primer caso asociado a policitemia vera y un nuevo caso asociado a mielodisplasia. Actas Dermosifiliogr. 2016;107:e27-32.

X. Kyriakou A, Patsatsi A, Papadopoulos V, Kioumi A, et ál. A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia. Clin Case Rep. 2019;7:695-698.

XI. Akinshemoyin Vaughn O, Siegel DH, Chiu YE, DeBord LC, et ál. Clinical and histologic presentation of pediatric reactive granulomatous dermatitis. Pediatr Dermatol. 2020;37:498-503.

XII. Błażewicz I, Szczerkowska-Dobosz A, Peksa R, Stawczyk-Macieja M, et ál. Interstitial granulomatous dermatitis: a characteristic histological pattern with variable clinical manifestations. Postepy Dermatol Alergol. 2015;32:475-477.

XIII. Santos-Alarcón S, López-López OF, Flores-Terry MA, Villamil-Cerda D, et ál. Collagen anomalies as clues for diagnosis. Part 2. Am J Dermatopathol. 2017;39:559-586.

XIV. Stephenson S, Campbell S, Drew GS, Magro CM. Palisaded neutrophilic and granulomatous dermatitis presenting in a patient with rheumatoid arthritis on adalimumab. J Cutan Pathol. 2011;38:644-648.

XV. Singh P, Wolfe SP, Alloo A, Gottesman SP. Interstitial granulomatous dermatitis and granulomatous arteritis in the setting of PD-1 inhibitor therapy for metastatic melanoma. J Cutan Pathol. 2020;47:65-69.

XVI. Magro CM, Crowson AN, Schapiro BL. The interstitial granulomatous drug reaction: a distinctive clinical and pathological entity. J Cutan Pathol. 1998;25:72-78.

XVII. Rodríguez-Garijo N, Bielsa I, Mascaró JM Jr, Quer A, et ál. Reactive granulomatous dermatitis as a histologic pattern including manifestations of interstitial granulomatous dermatitis and palisaded neutrophilic and granulomatous dermatitis: A study of 52 patients. J Eur Acad Dermatol Venereol. 2021;35:988-994.

XVIII. Sugioka K, Goto H, Sugita K, Habe K, et ál. Palisaded neutrophilic granulomatous dermatitis, interstitial granulomatous dermatitis and IgA vasculitis associated with incomplete Sjögren’s syndrome. J Dermatol. 2021;48:556-558.

XIX. Coutinho I, Pereira N, Gouveia M, Cardoso JC, et ál. Interstitial granulomatous dermatitis: a clinicopathological study. Am J Dermatopathol. 2015;37:614-619.

XX. Perez-Chua TA, Kisel YG, Chang KH, Bhawan J. Morphea and its variants and the “floating sign” an additional finding in morphea. Am J Dermatopathol. 2014;36:500-505.

XXI. Verneuil L, Dompmartin A, Comoz F, Pasquier CJ, et ál. Interstitial granulomatous dermatitis with cutaneous cords and arthritis: A disorder associated with autoantibodies. J Am Acad Dermatol. 2001;45:286-291.

XXII. Ruiz Soliz C, Ruiz Lascano A. Granuloma anular generalizado: Comunicación de dos casos y revisión de la literatura. Arch Argent Dermatol. 2003;53:257-261.

XXIII. Ahmed ZS, Joad S, Singh M, Bandagi SS. Interstitial granulomatous dermatitis successfully treated with etanercept. Am J Case Rep. 2014;15:94-96.

Published

2022-06-01

Issue

Section

Original Articles