Miescher’s granulomatous cheilitis treated with hydroxychloroquine

Authors

  • María Laura Marchese Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina
  • María Victoria Montes Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina
  • Julieta Ruiz Beguerie Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina
  • Javier Anaya Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina
  • Corina Busso Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v28i2.2267

Keywords:

granulomatous cheilitis, Miescher cheilitis, Melkersson-Rosenthal syndrome, orofacial granulomatosis

Abstract

Miescher's granulomatous cheilitis is a rare entity characterized by recurrent lip swelling. It represents the monosymptomatic form of Melkersson-Rosenthal syndrome which is defined by lip edema, facial paralysis and fissured tongue. In its histology is common the presence of non caseating granulomas. This entity is characterized by its difficult handling and the variable responses to the elected treatment. We present a patient who had an excellent response to treatment with hydroxychloroquine.

Author Biographies

María Laura Marchese, Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina

Dermatologist. Staff Physician, Dermatology Service, HUA, Pilar

María Victoria Montes, Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina

Second Year Dermatology Resident Physician, HUA, Pilar

Julieta Ruiz Beguerie, Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina

Dermatologist. Staff Physician, Dermatology Service, HUA, Pilar

Javier Anaya, Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina

Dermatopathologist. Staff Physician, Pathological Anatomy Service, HUA, Pilar

Corina Busso, Austral University Hospital (HUA), Austral University, Pilar, Province of Buenos Aires, Argentina

Dermatologist. Head of the Dermatology Service, HUA, Pilar

References

I. Martínez Martínez ML, Azaña-Defez JM, Pérez-García LJ, López-Villaescusa MT, et ál. Queilitis granulomatosa. Presentación de 6 casos y revisión de la literatura. Actas Dermosifiliogr. 2012;103:718-724.

II. Martínez Martínez ML, Azaña-Defez López JM, Villaescusa MT, Faura Berruga C, et ál. Diagnóstico y tratamiento de las granulomatosis orofaciales. Piel. 2013;28:402-407.

III. van der Waal RI, Schulten EA, van der Meij EH, van de Scheur MR, et ál. Cheilitis granulomatosa: overview of 13 patients with long-term follow-up–results of management. Int J Dermatol. 2002;41:225-229.

IV. Wehl G, Rauchenzauner M. A systematic review of the literature of the three related disease entities cheilitis granulomatosa, orofacial granulomatosis and Melkersson-Rosenthal syndrome. Curr Pediatr Rev 2018;14:196-203.

V. Romano MF, Filice PA, Lauro MF, Peláez O, et ál. Queilitis granulomatosa como parte del síndrome de Melkersson Rosenthal. Dermatol Argent. 2014;20:339-343.

VI. Ratzinger G, Sepp N, Vogetseder W, et ál. Cheilitis granulomatosa and Melkersson-Rosenthal syndrome: evaluation of gastrointestinal involvement and therapeutic regimens in a series of 14 patients. J Eur Acad Dermatol Venereol. 2007;21:1065-1070.

VII. Banks T, Gada S. A comprehensive review of current treatments for granulomatous cheilitis. Br J Dermatol. 2012;166:934-937.

VIII. Sobjanek M, Michajłowski I, Zelazny I, Medrzycka-Dabrowska W, et ál. What is the most effective treatment of cheilitis gra- nulomatosa in Melkersson-Rosenthal syndrome? J Eur Acad Dermatol Venereol. 2010;24:364-365.

IX. Wang S, Wang H, Shi X, Wu F, et ál. A case of Melkersson-Rosenthal syndrome with endocrine disorders: Extraordinary efficiency of hydroxychloroquine and mechanism hypothesis. Eur J Neurol. 2021;28:928-933.

Revista de la Sociedad Argentina de Dermatología N° 2 de 2022

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Published

2022-06-01

Issue

Vol. 28 No. 2 (2022): April-June 2022

Section

Clinical Cases

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