Progressive macular hypomelanosis: response to treatment with minocycline

Authors

  • Fátima Giusti Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina
  • Carlos Consigli Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina
  • Javier Consigli Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina
  • Lorena Cippitelli Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina
  • Marco Mazzotta Pathological Anatomy Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina

DOI:

https://doi.org/10.47196/da.v25i1.2199

Keywords:

progressive macular hypomelanosis, C. acnes, tetracyclines, minocycline, Wood’s light

Abstract

Progressive macular hypomelanosis (PMH) is a dermatosis characterized by hypopigmented macules, most frequently found in females and in phototypes III and IV. Cutibacterium acnes (C. acnes) type III has been associated as an etiological factor.

We present the case of a thirty-year-old female patient with a 10-year history of nummular hypopigmented macules located on the top of the lower limbs and on the trunk. The histological study reported a decrease in the number of melanocytes and melanotic pigment in the basal layer and the presence of superficial perivascular mononuclear inflammatory infiltrate. After an 8-month regimen of oral minocycline 100 mg/day, there was a complete resolution of the lesions.

Author Biographies

Fátima Giusti, Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina

Concurrent Medical Doctor

Carlos Consigli, Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina

Associate Professor

Javier Consigli, Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina

Associate Professor

Lorena Cippitelli, Dermatology Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina

Associate Professor

Marco Mazzotta, Pathological Anatomy Service, National Hospital of Clinics, Faculty of Medical Sciences, National University of Córdoba, Córdoba, Argentina

Staff Medical Doctor

References

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Published

2021-03-30

Issue

Vol. 27 No. 1 (2021): January-March 2021

Section

Clinical Cases

License

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