Enfermedad de injerto contra huésped cutánea frente a necrólisis epidérmica tóxica en un receptor de trasplante de células madre hematopoyéticas

Paula Johana Barba; Pilar Targize Vaquero; Mónica Melamed

doi:10.47196/da.v27i3.2120

Authors

Paula Johana Barba General Interzonal Acute Hospital Prof. Dr. Rodolfo Rossi, La Plata, Buenos Aires, Argentina
Pilar Targize Vaquero General Interzonal Acute Hospital Prof. Dr. Rodolfo Rossi, La Plata, Buenos Aires, Argentina
Mónica Melamed General Interzonal Acute Hospital Prof. Dr. Rodolfo Rossi, La Plata, Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v27i3.2120

Keywords:

graft versus host disease, toxic epidermal necrolysis, acute graft versus host disease, cutaneous graft versus host disease

Abstract

The differential diagnosis between severa graft-versus-host disease (stage IV) and toxic epidermal necrolysis can be difficult in the context of a transplant patient, since both conditions have similar clinical presentations. However, the distinction between these two entities is critical because they produce great morbidity and mortality and their management and prognosis differ. Some small clinical and histopathological differences ahre of great help for the differential diagnosis, and the dermatologist must recognize them in order to take a correct and timely conduct. We present the case of a patient who developed blisters and epidermolysis after hematopoietic cell transplantation, and in whom the diagnostic difficulty to differentiate between the two entities was raised.

Author Biographies

Paula Johana Barba, General Interzonal Acute Hospital Prof. Dr. Rodolfo Rossi, La Plata, Buenos Aires, Argentina

Staff Physician, Dermatology Service

Pilar Targize Vaquero, General Interzonal Acute Hospital Prof. Dr. Rodolfo Rossi, La Plata, Buenos Aires, Argentina

Resident Physician, Dermatology Service

Mónica Melamed, General Interzonal Acute Hospital Prof. Dr. Rodolfo Rossi, La Plata, Buenos Aires, Argentina

Staff Physician, Dermatology Service

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