Cocaine induced facial midline destructive ulcer

Authors

  • Martina Buffetti Dermatology Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Jesica Eliana Radonich Dermatology Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Melanie Reichardt Dermatology Service, Hospital Churruca Visca, Autonomous City of Buenos Aires, Argentina
  • Eliana Céfalo Pathological Anatomy Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina
  • Miguel Ángel Mazzini Dermatology Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v26i3.2101

Keywords:

cocaine, levamisole, midline facial ulcer

Abstract

Nowadays there is a growing incidence of skin manifestations due to cocaine abuse with a wide clinical range. Its origin can be traced to multiple factors: the vasoconstrictive effect of the drug, the irritant effects if adulterants like levamisole which induce dopaminergic and serotoninergic responses, and the traumatic effect of the mucosa caused by cocaine crystals insuflated at high velocity. There is yet no consensus on how to handle this pathology.

We report a 50-year-old male patient with an ulcer in nasal mucosa and adjacent tissues, secondary to cocaine use, with good response to treatment.

Author Biographies

Martina Buffetti, Dermatology Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Resident Doctor of Dermatology, Churruca Visca Hospital

Jesica Eliana Radonich, Dermatology Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Chief Resident Doctors of Dermatology, Churruca Visca Hospital

Melanie Reichardt, Dermatology Service, Hospital Churruca Visca, Autonomous City of Buenos Aires, Argentina

Resident Doctor of Dermatology, Churruca Visca Hospital

Eliana Céfalo, Pathological Anatomy Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Medical Doctor

Miguel Ángel Mazzini, Dermatology Service, Churruca Visca Hospital, Autonomous City of Buenos Aires, Argentina

Head of the Dermatology Service, Churruca Visca Hospital

References

I. Salas-Espíndola Y, Peniche-Castellanos A, López-Gehrke I, Mercadillo-Pérez P. Vasculitis leucocitoclástica asociada a consumo de cocaína. Actas Dermosifilogr 2011;102:825-827.

II. Barrera OM, De la Rivera VM, Vela UJ, Barrera MR, ét al. Lesiones destructivas de la línea media facial secundarias al consumo de cocaína. Caso clínico. Rev Med Chile 2018;146:1070-1073.

III. Trimarchi M, Gregorini G, Facchetti F, Morassi ML, ét al. Cocaine-induced midline destructive lesions: clinical, radiographic, histopathologic, and serologic features and their differentiation from Wegener granulomatosis. Medicine (Baltimore) 2001;80:391‐404.

IV. Calligaris M, Nipoti J, Gorosito M, Garrido MG. Vasculitis inducida por cocaína. Dermatol Argent 2017;23:196-198.

V. Roverano S, Gallo J, Ortiz A, Paira S. Manifestaciones sistémicas asociadas al consumo de cocaína: comunicación de un caso. Rev Argent Reumatol 2016;27:50-52.

VI. Trimarchi M, Bondi S, Della Torre E, Terreni MR, et ál. Palate perforation differentiates cocaine- induced midline destructive lesions from granulomatosis with polyangiitis. Acta Otorhinolaryngol Ital 2017;37:281-285.

VII. Fernández Blanco G, Madeo MC, Martínez M, Vázquez ME. Case for diagnosis. Palate perforation due to cocaine use. An Bras Dermatol 2017;92:877-878.

VIII. Trimarchi M, Bussi M, Sinico RA, Meroni P, et ál. Cocaine-induced midline destructive lesions - An autoinmune disease? Autoimmun Rev 2013;12:496-500.

Downloads

Published

2020-09-15

Issue

Vol. 26 No. 3 (2020): July-September 2020

Section

Clinical Cases

License

El/los autor/es tranfieren todos los derechos de autor del manuscrito arriba mencionado a Dermatología Argentina en el caso de que el trabajo sea publicado. El/los autor/es declaran que el artículo es original, que no infringe ningún derecho de propiedad intelectual u otros derechos de terceros, que no se encuentra bajo consideración de otra revista y que no ha sido previamente publicado.

 

Le solicitamos haga click aquí para imprimir, firmar y enviar por correo postal la transferencia de los derechos de autor