Ulceración esofágica por ingestión de doxiciclina

Santiago Pereda; Fernando Miguel  Stengel; Juliana Förster Fernández

doi:10.47196/da.v27i2.2092

Authors

Santiago Pereda Faculty of Medicine, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina
Fernando Miguel Stengel Buenos Aires Skin, Autonomous City of Buenos Aires, Argentina
Juliana Förster Fernández Buenos Aires Skin, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v27i2.2092

Keywords:

pill ulcer, esophageal ulceration, doxycycline

Abstract

Esophageal ulceration due to ingestion of doxycycline is one of the most frequent causes of esophageal injury. It has been underdiagnosed and scarcely recognized in dermatology. Retrosternal pain, sudden odynophagia and a history of doxycycline or other drugs intake are some of the characteristics that lead to diagnosis. It may cause severe complications such as bleeding, stenosis and mediastinitis.

Author Biographies

Santiago Pereda, Faculty of Medicine, University of Buenos Aires, Autonomous City of Buenos Aires, Argentina

Student

Fernando Miguel Stengel, Buenos Aires Skin, Autonomous City of Buenos Aires, Argentina

Dermatologist, Medical Director Buenos Aires Skin. Medical Clinic Residence, Model Institute, University of Buenos Aires, Rawson Hospital. Dermatology Residency, New York University, Department of Dermatology, USA. Assistant Professor of Dermatology, New York University. Former Head of the Dermatology Service (Int), Hospital de Clínicas José de San Martín, UBA. Former Head of CEMIC Dermatology Service, Buenos Aires. Former Associate Professor of Dermatology, CEMIC

Juliana Förster Fernández, Buenos Aires Skin, Autonomous City of Buenos Aires, Argentina

Dermatologist, Founding Partner of Buenos Aires Skin. Specialist in Dermatology Argentine Society of Dermatology. Former doctor of the Dermatology Service, Hospital de Clínicas José de San Martín, University of Buenos Aires. Founding Partner of the Skin Cancer Foundation, Buenos Aires, Argentina

References

I. Kikendall JW. Pill esophagitis. J Clin Gastroenterol. 1999;28:298-305.

II. Shetty AK. Tetracyclines in pediatrics revisited. Clin Pediatr. 2002;41:203-209.

III. Gencosmanoglu R, Kurtkaya-Yapicier O, Tiftikci A, et ál. Mid-esophageal ulceration and candidiasis-associated distal esophagitis as two distinct clinical patterns of tetracycline or doxycycline-induced esophageal injury. J Clin Gastroenterol 2004;38:484-489.

IV. Hey H, Jørgensen F, Sørensen K, et ál. Esophageal transit of six commonly used tablets and capsules. Br Med J. 1982;285:1717-1719.

V. Pace F, Antinori S, Repici A. What is new in esophageal injury (infection, drug-induced, caustic, stricture, perforation)? Curr Op Gastroenterol. 2009;25:372-379.

VI. Katzka DA. Esophageal disorders caused by medications, trauma, and infection. En: Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fortrand’s Gastrointestinal and Liver Disease. Philadeplhia: Elsevier; 2021:662.