Bullous pemphygoid and blisters in the newborn

Authors

  • María Laura Marchese Dermatology Service, Austral University Hospital, Province of Buenos Aires, Argentina
  • María Walker Dermatology Service, Austral University Hospital, Province of Buenos Aires, Argentina
  • Alejandro Olivera Dermatology Service, Austral University Hospital, Buenos Aires, Argentina
  • Javier Anaya Pathological Anatomy, Austral University Hospital, Buenos Aires, Argentina
  • Corina Busso Dermatology Service, Austral University Hospital, Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v26i1.2067

Keywords:

Pregnancy dermatosis, Bullous pemphygoid, Blister diseases

Abstract

Gestational pemphigoid is a rare, autoimmune dermatosis that occurs during pregnancy. It is characterized by an autoimmune response against hemidesmosome proteins, generating a cleavage between the epidermis and the dermis in the skin and mucous membranes. Clinically it presents with intense pruritus, plaques and erythematous papules that evolve to blisters that are distributed mainly in the abdomen and limbs. The complications are preterm birth and low weight for gestational age, with high risk of mortality.

Author Biographies

María Laura Marchese, Dermatology Service, Austral University Hospital, Province of Buenos Aires, Argentina

Dermatologist, Staff Physician of the Dermatology Service, Austral Hospital

María Walker, Dermatology Service, Austral University Hospital, Province of Buenos Aires, Argentina

Dermatologist, Staff Medical Doctor of the Dermatology Service, Austral Hospital

Alejandro Olivera, Dermatology Service, Austral University Hospital, Buenos Aires, Argentina

Pediatric Dermatologist, Staff Medical Doctor of the Dermatology Service, Austral Hospital

Javier Anaya, Pathological Anatomy, Austral University Hospital, Buenos Aires, Argentina

Dermatopathologist, Staff Medical Doctor of the Pathological Anatomy Service, Austral Hospital

Corina Busso, Dermatology Service, Austral University Hospital, Buenos Aires, Argentina

Master in Clinical and Pharmacological Research, Dermatologist, Head of the Dermatology Service, Austral Hospital

References

I. Ambros-Rudolph CM. Dermatoses of pregnancy – clues to diagnosis, fetal risk and therapy. Ann Dermatol 2011;23:265-275.

II. Ambros-Rudolph CM, Müllegger RR, Vaughan-Jones SA, Kerl H, et ál. The specific dermatoses of pregnancy revisited and reclassified: results of a retrospective two-center study on 505 pregnant patients. J Am Acad Dermatol 2006;54:395-404.

III. Al-Saif F, Elisa A, Al-Homidy A, Al-Ageel A, et ál. Retrospective analysis of pemphigoid gestationis in 32 Saudi patients – clinicopathological features and a literature review. J Reprod Immunol 2016;116:42-45.

IV. Huilaja L, Mäkikallio K, Sormunen R, Lohi J, et ál. Gestational pemphigoid: placental morphology and function. Acta Derm Venereol 2013;93:33-38.

V. Borthwick GM, Sunderland CA, Holmes RC, Black MM, et ál. Abnormal expression of HLA-DR antigen in the placenta of a patient with pemphigoid gestationis. J Reprod Immunol 1984;6:393-396.

VI. Roth MM. Pregnancy dermatoses diagnosis, management, and controversies. Am J Clin Dermatol 2011;12:25-41.

VII. Semkova K, Black M. Pemphigoid gestationis: current insights into pathogenesis and treatment. Eur J Obstet Gynecol Reprod Biol 2009;145:138-144.

VIII. Hallaji Z, Mortazavi H, Ashtari S, Nikoo A, et ál. Pemphigoid gestationis: clinical and histologic features of twenty three patients. Int J Womens Dermatol 2016;3:86-90.

IX. Jenkins RE, Hern S, Black MM. Clinical features and management of 87 patients with pemphigoid gestationis. Clin Exp Dermatol 1999;24:255-259.

X. Jenkins RE, Jones SA, Black MM. Conversion of pemphigoid gestationis to bullous pemphigoid-two refractory cases highlighting this association. Br J Dermatol 1996;135:595-598.

Published

2020-03-15

Issue

Section

Clinical Cases