Tamara Fedra Limanski; Cecilia Inés Crowe; Mariano Gabriel Marini

Authors

Tamara Fedra Limanski Güemes Sanatorium, Autonomous City of Buenos Aires, Argentina
Cecilia Inés Crowe Güemes Sanatorium, Autonomous City of Buenos Aires, Argentina
Mariano Gabriel Marini Güemes Sanatorium, Autonomous City of Buenos Aires, Argentina

Keywords:

iatrogenic calcinosis cutis, sodium thiosulfate

Abstract

Calcinosis cutis is the deposit of calcium salts in the skin. The iatrogenic form is secondary to parenteral treatment with calcium salts. Calcium gluconate is administered intravenously in preterm infants for the treatment of hypocalcemia. When extravasation occurs, it is deposited in the dermis and/or hypodermis and manifests clinically, as nodules or subcutaneous plaques. The diagnosis is made by the history and imaging studies. The treatment is not protocolized.
A 50-day-old infant is presented with a diagnosis of iatrogenic calcinosis cutis on the back of a hand that was treated with 10% topical sodium thiosulfate with a favorable response.

Author Biographies

Tamara Fedra Limanski, Güemes Sanatorium, Autonomous City of Buenos Aires, Argentina

Pediatric Dermatologist. Pediatric Dermatology Section, Dermatology Service

Cecilia Inés Crowe, Güemes Sanatorium, Autonomous City of Buenos Aires, Argentina

Pediatric Dermatologist. Pediatric Dermatology Section, Dermatology Service

Mariano Gabriel Marini, Güemes Sanatorium, Autonomous City of Buenos Aires, Argentina

Head of the Service. Pediatric Dermatology Section, Dermatology Service

References

I. García-García E, López-López R, Álvarez-Del-Vayo C, Bernabeu-Wittel J. Iatrogenic calcinosis cutis successfully treated with topical sodium thiosulfate. Pediatr Dermatol 2017;34:356-358.

II. Pérez-Moreno M A, Álvarez del Vayo-Benito C, Flores-Moreno S, Bernabeu-Wittel J. Calcinosis cutánea grave tratada exitosamente con una fórmula magistral tópica W/O de tiosulfato sódico al 10%. Acta Pediatr Esp 2014;72: e9-e10.

III. Ma JE, Ernste FC, Davis MDP, Wetter DA. Topical sodium thiosulfate for calcinosis cutis associated with autoimmune connective tissue diseases: the Mayo Clinic experience, 2012-2017. Clin Exp Dermatol 2019;44:e189-e192.

IV. Moss J, Syrengelas A, Antaya R, Lazova R. Calcinosis cutis: a complication of intravenous administration of calcium gluconate. J Cutan Pathol 2006;33:60-62.

V. Arora A, Agarwal A, Kumar S, Gupta SK. Iatrogenic calcinosis cutis a rare differential diagnosis of soft-tissue infection in a neonate: a case report. J Orthop Surg2005;13:195-198.

VI. Kagen MH, Bansal MG, Grossman M. Calcinosis cutis following the administration of intravenous calcium therapy. Cutis 2000;65:193-194.

VII. Topham C, Haynes D, Frigerio A, Hull C. Linear amyopathic dermatomyositis with calcinosis cutis responsive to topical sodium thiosulfate. Pediatr Dermatol 2019;36:e102-e103.

VIII. Tajalli M, Qureshi A.Successful treatment of calcinosis cutis of fingertip in the setting of CREST syndrome with topical 20% sodium thiosulfate. JAAD Case Report 2019;5:988-990.

IX. Strazzula L, Nigwekar SU, Steele D, Tsiaras W, et ál. Intralesional sodium thiosulfate for the treatment of calciphylaxis. JAMA Dermatol 2013;149:946-949.