Oral cancer prevention campaign in Mendoza: retrospective study of 5 years

Authors

  • Adriana Senarega Luis C. Lagomaggiore Hospital, Mendoza, Argentina
  • María Jimena Fernández Tapia Luis C. Lagomaggiore Hospital, Mendoza, Argentina
  • Jorgelina Vidal Luis C. Lagomaggiore Hospital, Mendoza, Argentina
  • Emilce Rivarola Luis C. Lagomaggiore Hospital, Mendoza, Argentina
  • María Eugenia Ingrassia Tonelli National University of Cuyo, Mendoza, Argentina
  • Isabel Rosa Bongiovanni National University of Cuyo, Mendoza, Argentina
  • Viviana Parra Luis C. Lagomaggiore Hospital, Mendoza, Argentina

Keywords:

mouth neoplasms, potentially malignant disorders, prevention campaig

Abstract

Background: mouth neoplasms (MN) has a high mortality rate. For this reason, preventive campaigns have been developed.

Objective: to determine the epidemiological and clinical-pathological features of the patients evaluated in prevention oral cancer campaigns in Mendoza along 5 years.

Design: descriptive, retrospective, observational and cross sectional study.

Methods: patients evaluated in the MN campaigns that were performed in Mendoza from 2013 to 2017 were collected. The variables studied were: age, sex, risk factors (trauma, tobacco and alcoholism), injury and localization. The analysis was performed with Graph Pad Instat 3 and EpiInfo 7 software. Measures of central tendency, dispersion and cross product ratio (OR) were used.

Results: data were obtained from 4486 patients. 64.48% were women (2893 patients) and the mean age was 46.73 years (± 19.6 years). Pathological findings were detected in 43.91% (1970 patients). Of these, 0.41% corresponded to MN. The predominant tumor was squamous cell carcinoma and the most common localization was the tongue. 23.05% (454 patients) were potentially malignant lesion (PML). Leukoplakia was the predominant lesion and jugal mucosa the most affected site. There was a predominance of alcoholism, smoking and trauma in patients with MN or PML, with an OR of 1.41, 1.18 and 5.12 respectively.

Conclusions: our study coincided with the types of MN and PML, the localization and the main risk factors (tobacco and alcoholism) found. A higher proportion of associated trauma was observed.

Author Biographies

Adriana Senarega, Luis C. Lagomaggiore Hospital, Mendoza, Argentina

Resident Physician of Dermatology

María Jimena Fernández Tapia, Luis C. Lagomaggiore Hospital, Mendoza, Argentina

Resident Physician of Dermatology

Jorgelina Vidal, Luis C. Lagomaggiore Hospital, Mendoza, Argentina

Chief Resident of Dermatology

Emilce Rivarola, Luis C. Lagomaggiore Hospital, Mendoza, Argentina

Medical Doctor, Dermatologist

María Eugenia Ingrassia Tonelli, National University of Cuyo, Mendoza, Argentina

Dentist

Isabel Rosa Bongiovanni, National University of Cuyo, Mendoza, Argentina

Dentist

Viviana Parra, Luis C. Lagomaggiore Hospital, Mendoza, Argentina

Head of the Dermatology Service

References

I. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009;45:309-316.

II. Warnakulasuriya S. Causes of oral cancer–an appraisal of controversies. Br Dent J 2009;207:471-475.

III. National Cancer Institute. Tratamiento del cáncer de labio y de cavidad oral (PDQ®). Versión para profesionales de la salud. 2017;1-4.

IV. Santelices MJ, Cárcamo M, Brenner C, Montes R. Oral cancer. Review of the Chilean literature. Rev Med Chile 2016;44:766-770.

V. GLOBOCAN 2012. Estimated Cancer Incidence, Mortality and Prevalence in Worlwide in 2012.

VI. Dhanuthai K, Rojanawatsirivej S, Subarnbhesaj A, Thosaporn W, et ál. A multicenter study of oral malignant tumors from Thailand. J Oral Maxillofac Pathol 2016;20:462-466.

VII. Sociedad Argentina de Dermatología 2005. Consenso sobre Carcinoma Basocelular-Carcinoma Espinocelular. Guía de Recomendaciones.

VIII. Perry BJ, Zammit AP, Lewandowski AW, Bashford JJ, et ál. Sites of origin of oral cavity cancer in nonsmokers vs. smokers possible evidence of dental trauma carcinogenesis and its importance compared with Human Papillomavirus. JAMA Otolaryngol Head Neck Surg 2015;141:5-11.

IX. Kashyap RR, Kashyap RS. Self-inflicted injury as a potential trigger for carcinoma of lip–a case report. Gerodontology2013;30:236-238.

X. Albuquerque R, López-López J, Marí-Roig A, Jané-Salas E, et ál. Relationship between squamous cell carcinoma of the anterior two thirds of the tongue and removable denture use. A Pioneer Study in a Portuguese Population. Braz Dent J2011;22:410-414.

XI. Hegarty AM, Hunter KD. Oral malignancy and premalignancy. Br J Hosp Med 2016;77:232-239.

XII. López-López J, Omaña-Cepedab C, Jané-Salas E. Precáncer y cáncer bucal. Med Clin (Barc) 2015;145:404-408.

XIII. Monteiro LS, Salazar F, Pacheco JJ, Martins M, et ál. Outcomes of invitational and opportunistic oral cancer screening initiatives in Oporto, Portugal. J Oral Pathol Med 2015;44:145-152.

XIV. García-Pola Vallejo MJ, Martínez Díaz-Canel AI, García Martín JM, González García M. Risk factors for oral soft tissue lesions in an adult Spanish population. Community Dent Oral Epidemiol 2002;30:277-285.

XV. Do LG, Spencer AJ, Dost F, Farah CS. Oral mucosal lesions: findings from the Australian National Survey of Adult Oral Health. Aust Dent J 2014;59:114-120.

XVI. Ramadas K, Arrossi S, Thara S, Thomas G, et ál. Which socio-demographic factors are associated with participation in oral cancer screening in the developing world ? Results from a population-based screening project in India. Cancer Detect Prev 2008;32:109-115.

XVII. Nemoto RP, Victorino AA, Pessoa GB, Cunha LL, et ál. Oral cancer preventive campaigns: are we reaching the real target ? Braz J Otorhinolaryngol 2015;81:44-49.

XVIII. Feng J, Zhou Z, Shen X, Wang Y, et ál. Prevalence and distribution of oral mucosal lesions: a cross-sectional study in Shanghai, China. J Oral Pathol Med 2015;4:490-494.

XIX. Morelatto RA, López de Blanc SA. Mortalidad por cáncer bucal en la provincia de Córdoba, República Argentina (período 1975-2000). Estudio comparativo con otras poblaciones. Med Oral Patol Oral Cir Bucal 2006;11:230-235.

XX. Brandizzi D, Gandolfo M, Velazco ML, Cabrini RL, et ál. Clinical features and evolution of oral cancer: A study of 274 cases in Buenos Aires, Argentina. Med Oral Patol Oral Cir Bucal2008;13:544-548.

Published

2018-03-15

Issue

Section

Original Articles