Eosinophilic ulcer of the tongue

Authors

  • María Victoria Itatí Cordo Platense Medical Institute, La Plata, Buenos Aires, Argentina
  • Ramiro Luna Cian Platense Medical Institute, La Plata, Buenos Aires, Argentina
  • Ana Karina Ochoa Platense Medical Institute, La Plata, Buenos Aires, Argentina
  • Roberto Castelletto Private Practice, Buenos Aires, Argentina

Keywords:

eosinophilic ulcer, oral cavity, tongue

Abstract

Traumatic granuloma with stromal eosinophilia or eosinophilic ulcer is a rare inflammatory, benign condition that affects the oral cavity, in particular the tongue. Histologically, it is characterized by a denuded epithelium with granulomatous inflammation and abundant eosinophils, sometimes there may be lymphocytic atypia simulating a CD30 positive lymphoproliferative process. It is usually autoinvolutive, although it may be treated with topical or systemic corticosteroids, or surgical excision. We must remember it among the differential diagnoses of oral cavity ulcers.

Author Biographies

María Victoria Itatí Cordo, Platense Medical Institute, La Plata, Buenos Aires, Argentina

Staff Physician, Dermatology Service

Ramiro Luna Cian, Platense Medical Institute, La Plata, Buenos Aires, Argentina

Staff Physician, Dermatology Service

Ana Karina Ochoa, Platense Medical Institute, La Plata, Buenos Aires, Argentina

Staff Physician, Dermatology Service

Roberto Castelletto, Private Practice, Buenos Aires, Argentina

Medical Specialist in Pathology

References

I. Segura S, Pujol RM. Eosinophilic ulcer of the oral mucosa: a distinct entity or a non-specific reactive pattern? Oral Dis2008;14:287-295.

II. Elzay RP. Traumatic ulcerative granuloma with stromal eosinophilia (Riga-Fede’s disease and traumatic eosinophilic granuloma). Oral Surg Oral Med Oral Pathol 1983;55:497-506.

III. Segura S, Romero D, Mascaró JM, Colomo L, et ál. Eosinophilic ulcer of the oral mucosa: another histological simulator of CD30+ lymphoproliferative disorders. Br J Dermatol2006;155:460-463.

IV. Shen WR, Chang JY, Wu YC, Cheng SJ, et al. Oral traumatic ulcerative granuloma with stromal eosinophilia: A clinicopathological study of 34 cases. J Formos Med Assoc2015;114:881-885.

V. Schultz G, Rotatori DS, Clark W. EGF and TGF-alpha in wound healing and repair. J Cell Biochem 1991;45:346-352.

VI. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu Rev Immunol 1998;16:137-161.

VII. Hong M, Ko YH. CD30-Positive T-cell lymphoproliferative disease of the oral mucosa in children: a manifestation of Epstein-Barr virus-associated T-lymphoproliferative disorder. J Pathol Transl Med 2015;49:525-530.

VIII. Chandra S, Raju S, Sah K, Anand P. Traumatic ulcerative granuloma with stromal eosinophilia. Arch Iran Med 2014;17:91-94.

Published

2018-03-01