Generalized cutaneous argyria due to prolonged application of silver sulfadiazine

Authors

  • María Belén Salvaneschi F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina
  • Margarita Jaled F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina
  • Liliana Olivares F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina
  • María Emilia Candiz F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina
  • Esteban Maronna F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina

Keywords:

argyria, silver poisoning, silver sulfadiazine

Abstract

Argyria is an infrequently disease. It manifests itself primarily as a blue-gray pigmentation of the skin and mucosa, without other systemic symptoms. The clinical feature, associated with the history of exposure and histopathology, allow the diagnosis. We report the case of a patient with chronic leg ulcers that topically applied silver sulfadiazine for 10 years, with the further development of generalized cutaneous argyria

Author Biographies

María Belén Salvaneschi, F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina

Concurrent Medical

Margarita Jaled, F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina

Medical Dermatologist

Liliana Olivares, F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina

Head of Unit

María Emilia Candiz, F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina

Medical Dermatologist, Former Resident Instructor

Esteban Maronna, F. J. Muñiz Hospital, Autonomous City of Buenos Aires, Argentina

Pathologist, Anatomical Pathology Service

References

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II. McClain CM, Kantrow SM, Abraham JL, Price J, et ál. Localized cutaneous argyria: two case reports and clinicopathologic review. Am J Dermatopathol 2013;35:e115-e118.

III. Sterling JP. Silver-resistance, allergy and blue skin: Truth or urban legend? Burns 2014;40:S19-S23.

IV. Gulbranson S, Hud J, Hansen R. Argyria following the use of dietary supplements containing colloidal silver protein. Cutis2000;66:373-374.

V. White JM, Powell AM, Brady K, Russell-Jones R. Severe gene-ralized argyria secondary to ingestion of colloidal silver pro-tein. Clin Exp Dermatol 2003;28:254-256.

VI. Garcias-Ladaria J, Hernández-Bel P, Torregrosa-Calatayud JL, Martínez-Aparicio A. Argiria cutánea localizada. A propósito de 2 casos. Actas Dermosifiliogr 2013;104:253-254.

VII. Enei ML, Macedo Paschoal F, Valdés R. Argyria mimicking a blue nevis: dermoscopy features. An Bras Dermatol 2013;88:452-455.

VIII. Astuto M, Chinchilla D, Singman M, Massone C, et ál. Argiria generalizada secundaria a sulfadiazina de plata tópica. Der-matol Argent 2014;20:335-338.

IX. Park S-W, Kim J-H, Shin H-T, Lee K-T, et ál. An effective modali-ty for argyria treatment: Q-Switched 1,064-nm Nd:YAG laser. Ann Dermatol 2013;25:511-512

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Published

2017-06-01

Issue

Vol. 23 No. 2 (2017): April-June 2017

Section

Clinical Cases

License

Copyright (c) 2017 Argentine Society of Dermatology

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