Methotrexate toxicity in a patient with psoriasis
Keywords:
toxicity, methotrexate, plaque psoriasisAbstract
Methotrexate is a folic acid antagonist widely used. It was the first drug approved for the systemic treatment of plaque psoriasis with arthropathy and it is used in weekly doses of 7.5 to 25 mg. Some patients experience adverse effects that can range from mild to fatal. This variability depends on multiple factors that must be consid-ered when prescribing it. We present a woman with psoriasis who self-medicated with high doses of methotrexate and developed mucocutaneous lesions as a sign of toxicity. These lesions included erosions of her psoriatic plaques, an uncommon manifestation that not be confused with an exacerbation of the underlying disease.
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