Merkel cell carcinoma
DOI:
https://doi.org/10.47196/ns8sdg98Keywords:
Merkel cell carcinoma, neuroendocrine, Merkel cell, polyomavirus, immunotherapyAbstract
Merkel cell carcinoma (MCC) is a rare and highly aggressive cutaneous neuroendocrine carcinoma, with a rising incidence worldwide. It predominantly affects Caucasian individuals, particularly older males and immunosuppressed patients. Its etiology is linked to mutations induced by ultraviolet (UV) radiation, as well as infection with an oncogenic virus: the Merkel cell polyomavirus (MCPyV). The typical clinical presentation is a rapidly growing, erythematoviolaceous tumor located in sun-exposed areas; however, other less common presentations have also been reported. Histopathology and immunohistochemistry confirm the diagnosis. Treatment options have expanded in recent decades, significantly improving the prognosis in advanced disease through a combination of surgery, radiation therapy, and systemic immunotherapy.
References
I. Hui Yu J, Khachemoune A. A review of Merkel cell carcinoma. JAAPA. 2023;36:11-16.
II. Mbous Y, Mohamed R, Sambamoorthi U, Bharmal M, et al. Effectiveness and safety of treatments for early-stage Merkel cell carcinoma: a systematic review and meta-analysis of randomized and non-randomized studies. Cancer Med. 2025;14:1-14.
III. Llombart B, Requena C, Cruz J. Actualización en el carcinoma de células de Merkel: Epidemiología, etiopatogenia, clínica, diagnóstico y estadificación. Actas Dermosifiliogr. 2017;108:108-119.
IV. Chai J, Tang Y, Chen Y, Liu Y. Merkel cell carcinoma case reports with Merkel cell polyomavirus test and review of the literature. Am J Dermatopathol. 2024;46:784-787.
V. Lugowska I, Becker J, Ascierto P, Veness M, et al. Merkel-cell carcinoma: ESMO-EURACAN Clinical practice guideline for diagnosis, treatment and follow-up. ESMO Open. 2024;9:1-14.
VI. Rosales P, Arteaga E, Pila R, Pila-Peláez R, et al. Carcinoma de células de Merkel: estudio de cuatro casos y revisión de aspectos relevantes. Med Cutan Iber Lat Am. 2010;38:16-22.
VII. Amber KA, McLeod MP, Nouri K. The Merkel cell polyomavirus and its involvement in Merkel cell carcinoma. Dermatol Surg. 2013;39:232-238.
VIII. Gauci ML, Aristei C, Becker JC, Blom A, et al. Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline. Update 2022. Eur J Cancer. 2022; 171:203- 231.
IX. Boyer JD, Zitelli JA, Brodland DG, D´Angelo G. Local control of primary Merkel cell carcinoma. Review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation. J Am Acad Dermatol. 2002;47:885- 892.
X. Beenken SW, Urist MM. Treatment options for Merkel cell carcinoma. J Natl Compr Canc Netw. 2004;2:89-92.
XI. Barquero-Orias DE, Landaverde-Recinos DU, Segura-Guevara JM. Carcinoma de células de Merkel: patogénesis, manejo y tratamientos emergentes. Rev Med Sinergia. 2019;4:15-23.
XII. Becker JC, Ugurel S, Stang A, Schrama D. Merkel cell carcinoma: integrating epidemiology, immunology, and therapeutic updates. Am J Clin Dermatol. 2024;25:541-557.
XIII. Konstantaraki M, Berdiaki A, Neagu M, Zurac S, et al. Understanding Merkel cell carcinoma: pathogenic signaling, extracellular matrix dynamics, and novel treatment approaches. Cancers (Basel). 2025;17:1-41.
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