Granulomatosis with polyangiitis limited variety

Authors

  • María Victoria Rosso Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina
  • Diego Martín Loriente Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina
  • Sandra García Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina
  • Patricia Silvia Della Giovanna Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina

Keywords:

granulomatosis with polyangiitis, Wegener`s granulomatosis, limited variety, vasculitis associated with ANCA

Abstract

Granulomatosis with polyangiitis (GPA) or Wegener´s granulomatosis is a vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCA). It is characterized by necrotizing granulomatous vasculitis of upper and lower respiratory tract, glomerulonephritis and small vessels vasculitis of variable degree. Up to fifty percent of patients have skin involvement. There are limited forms without glomerulonephritis that despite having a better prognosis can be very destructive at mucocutaneous level, generating severe disfiguring sequels, so it is important to know this variant of the disease for its diagnosis and early treatment. Two cases of GPA limited variety are presented and a bibliographic review is conducted.

Author Biographies

María Victoria Rosso, Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina

Former Chief of Residents of Dermatology, Dermatology Service

Diego Martín Loriente, Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina

Medical plant. Dermatology Service

Sandra García, Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina

Head of the Pathology Service. Dermatology Service

Patricia Silvia Della Giovanna, Professor Alejandro Posadas National Hospital, El Palomar, Buenos Aires, Argentina

Head of the Dermatology Service. Dermatology Service

References

I. Battagliotti CA, Kilstein JG. Definición y clasificación clínica. En: Battagliotti CA, Berbotto GA, Kilstein JG, Pons-Estel BA. Vasculitis sistémicas: toma de decisiones. Buenos Aires:Corpus;2015:17-25.

II. León-Ortiz AG, Guaman-Crespo JO,Sánchez-Zuñiga MJ, Carrillo-Esper R. Granulomatosis con poliangitis, granulomatosis de Wegener. Med Int Mex 2017;33:421-426.

III. Calzada Algrávez JA, Ramírez HJ, Delgadillo Márquez G, Macías Díaz DM. Granulomatosis de Wegener: presentación de un caso clínico y revisión de la bibliografía. Med Int Mex 2012;28:504-507.

IV. Berbotto GA, Mariño M,Battagliotti CA. Granulomatosis de Wegener. En: Battagliotti CA, Berbotto GA, Kilstein JG, Pons-Estel BA. Vasculitis sistémicas: toma de decisiones. Buenos Aires: Corpus; 2015:17-25.

V. Watts RA, Robson J. Introduction, epidemiology and classification of vasculitis. Best Pract ResClin Rheumatol 2018;32:3-20.

VI. Jennette JC, Falk RJ, Bacon PA, Basu N, et ál. 2012 Revised International Chapel Hill Consensus Conference. Nomenclature of Vasculitides. Arthitis Rheumatol 2013;65:1-11.

VII. Ponte C, Águeda AF, Luqmani RA. Clinical features and structured clinical evaluation of vasculitis. Best Pract Res ClinRheumatol2018;32:31-51.

VIII. Grygiel-Górniak B, Limphaibool N, Perkowska K y Puszczewicz M. Clinical manifestations of granulomatosis with polyangiitis: key considerations and major features. Postgrad Med 2018;130:518-596.

IX. Nakazawa D, Masuda S, Tomaru U, Ishizu A. Pathogenesis and therapeutic interventions for ANCA-associated vasculitis. Nat Rev Rheumatol 2018;15:91-101.

X. Radic M. Drug-Induced Vasculitis. En: Amezcua-Guerra, LM. Advances in the Etiology, Pathogenesis and Pathology of Vasculitis. Croacia:In Tech; 2011:275-286.

XI. Zuckerman R, Mayurkumar P, Costanzo EJ, Dounis H. Hidralazine-associated adverse events: a report of two cases of hidralazine-induced ANCA vasculitis. J Bras Nefrol 2017:193-197.

XII. Silva F, Cisternas M. Vasculitis asociadas a anticuerpos anti-citoplasma de neutrófilos: avances en patogenia y tratamiento. Rev Med Chile 2013;141:765-773.

XIII. Chen Ko-Ron. Skin involvement in ANCA-associated vasculitis. Clin Exp Nephrol 2013:17:676-682.

XIV. Comfere NI, Macaron NC, Gibson LE. Cutaneous manifestations of Wegener`s granulomatosis: a clinicopathologic study of 17 patients and correlation to antineutrophil cytoplasmic antibody status. J Cutan Pathol 2007;34:739-747.

XV. Trénor Larraz P, Martinez Cristóbal A, Pallardó Calatayud Y. Vasculitis sistémicas asociadas a ANCA: Granulomatosis de Wegener y Poliangeítis Microscópica. En: Belmonte MA, Castellano JA, Román JA, Rosas JC. Enfermedades reumáticas.Actualización SVR 2013:395-416.

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Published

2019-09-20

Issue

Vol. 25 No. 3 (2019): July-September 2019

Section

Original Articles

License

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