Stevens-Johnson Syndrome in a patient diagnosed with HIV and syphilis
DOI:
https://doi.org/10.47196/3qtnze21Keywords:
Stevens-Johnson syndrome, HIV, syphilis, drug induced skin reactionsAbstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare adverse drug reactions that are part of the same spectrum of disease. They are differentiated by the extent of skin detachment, and SJS is considered when it is less than 10%. The prevalence of SJS in HIV-positive patients is up to 1000 times higher than in the rest of the population, probably secondary to an alteration in the T-cell-mediated immune response. We present the case of a female patient with SJS who during hospitalization was diagnosed with HIV and syphilis, both unknown until now.
References
I. Racca-Velásquez F, Saurith-Daza ZJ, Benítez-Arce SC. Síndrome de Stevens-Johnson: informe de un caso. Salud i Ciencia 2024;26:203-209.
II. Hotzenecker W, Prins C, French LE. Eritema multiforme, síndrome de Stevens-Johnson y necrólisis epidérmica tóxica. En: Bolognia JL, Schaffer JV, Cerroni L, eds. Dermatología. 4º ed. Barcelona: Elsevier; 2018:337-345.
III. Lagrew M, Perryman K, Walker A, Hahn P. Stevens-Johnson Syndrome (SJS) as the initial presentation in a patient with a new diagnosis of HIV. Cureus. 2023;15:e50277.
IV. Tassier C, Anodal M, Villani ME, Sánchez G, et al. Farmacodermias: un estudio prospectivo. Dermatol Argent. 2014;20:176-187.
V. Jossy T, Maury T, Mutizwa M. HIV-associated toxic epidermal necrolysis at San Francisco General Hospital: a 13-year retrospective review. J Int Assoc Provid AIDS Care. 2017;16:37-41.
VI. Yang C, Mosam A, Mankahla A, Dlova N, et al. HIV infection predisposes skin to toxic epidermal necrolysis via depletion of skin-directed CD4+ T cells. J Am Acad Dermatol. 2014;70:1096-1102.
VII. Gómez A, Alvez I, Cabrera J. Farmacodermias severas: experiencia del Centro Nacional de Quemados (CENAQUE) de Montevideo, Uruguay. Rev Argent Quemaduras. 2020;30:1-9.
VIII. Hasegawa A, Abe R. Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis. F1000Res. 2020;9:612.
IX. Shah H, Parisi R, Mukherjee E, et al. Update on Stevens-Johnson syndrome and toxic epidermal necrolysis: diagnosis and management. Am J Clin Dermatol. 2024;25:891-908.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 on behalf of the authors. Reproduction rights: Argentine Society of Dermatology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
El/los autor/es tranfieren todos los derechos de autor del manuscrito arriba mencionado a Dermatología Argentina en el caso de que el trabajo sea publicado. El/los autor/es declaran que el artículo es original, que no infringe ningún derecho de propiedad intelectual u otros derechos de terceros, que no se encuentra bajo consideración de otra revista y que no ha sido previamente publicado.
Le solicitamos haga click aquí para imprimir, firmar y enviar por correo postal la transferencia de los derechos de autor
