Rheumatoid neutrophilic dermatosis

Authors

  • Mary Litzi Soliz Burgos Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina
  • María Laura Mauri Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina
  • Carmen Alfaro Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina
  • Patricia Silvia Della Giovanna Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina

DOI:

https://doi.org/10.47196/r7hhv247

Keywords:

rheumatoid arthritis, pyoderma gangrenosum, neutrophilic dermatosis

Abstract

Rheumatoid neutrophilic dermatosis (RND) is a rare skin condition associated with severe rheumatoid arthritis (RA). Clinically, it presents with papules, nodules, pustules, and occasionally vesicles, predominantly located on the joints and extremities. Diagnosis is confirmed through histopathology, which shows neutrophilic infiltration in the dermis. Initial treatment includes topical or systemic corticosteroids, although dapsone may be required in refractory cases. We report the case of a patient with RND associated with RA who exhibited an unusual polymorphic clinical presentation and histological evidence of neutrophilic infiltration. The disease was refractory to systemic corticosteroids but achieved complete remission following dapsone therapy

Author Biographies

  • Mary Litzi Soliz Burgos, Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina

    Chief Resident

  • María Laura Mauri, Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina

    Medical Specialist in Dermatology

  • Carmen Alfaro, Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina

    Physician specializing in Anatomic Pathology

  • Patricia Silvia Della Giovanna, Professor Alejandro Posadas National Hospital, Buenos Aires Province, Argentina

    Dermatologist, Head of the Dermatology Department

References

I. Manriquez J, Giesen L, Del Puerto C, González S. Rheumatoid arthritis and pseudo-vesicular skin plaques: rheumatoid neutrophilic dermatosis. An Bras Dermatol. 2016;91:500- 502.

II. Sayah A, English C. Rheumatoid arthritis: a review of the cutaneous manifestations. J Am Acad Dermatol. 2005;53:191-209.

III. Kumari I, Dongre A, Mohanty S. Rheumatoid neutrophilic dermatosis. The distinct entity with florid presentation. Indian Dermatol Online J. 2020;11:114-115.

IV. Lora V, Cerroni L, Cota C. Skin manifestations of rheumatoid arthritis. G Ital Dermatol Venereol. 2018;153:243-255.

V. Macaya A, Servitje O, Jucglà A, Peyrí J. Rheumatoid neutrophilic dermatitis associated with pyoderma gangrenosum. Br J Dermatol 2000;142:1246-1248.

VI. Kreuter A, Rose C, Zillikens D, Altmeyer P. Bullous rheumatoid neutrophilic dermatosis. J Am Acad Dermatol. 2005;52:916-918.

VII. Fujio Y, Funakoshi T, Nakayama K, Amagai M, et al. Rheumatoid neutrophilic dermatosis with tense blister formation: a case report and review of the literature. Australas J Dermatol. 2014;55:12-14.

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Published

2026-07-16

Issue

Vol. 32 No. 2 (2026): May–August

Section

Clinical Cases

License

Copyright (c) 2026 on behalf of the authors. Reproduction rights: Argentine Dermatology

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