Microcystic adnexal carcinoma of atypical location

Authors

  • Camila Anderlini Private University Hospital of Córdoba, Córdoba, Argentina
  • Gisel Astronave Private University Hospital of Córdoba, Córdoba, Argentina
  • Sofía Zanitti Private University Hospital of Córdoba, Córdoba, Argentina
  • Marco Mazzota Private University Hospital of Córdoba, Córdoba, Argentina
  • Enrique Valente Private University Hospital of Córdoba, Córdoba, Argentina

DOI:

https://doi.org/10.47196/da.v31i3.2970

Keywords:

adnexal microcystic carcinoma, adnexal tumour, Mohs micrographic surgery

Abstract

Microcystic adnexal carcinoma (MAC) is an infiltrative, rare adnexal tumor that arises from pluripotent cells with differentiation into both eccrine and follicular structures. We present a 43-year-old male patient with MAC in an atypical location on the dorsum of the left foot, situated on a previous scar. Despite its indolent behavior, it is locally aggressive and requires first-line surgical treatment, preferably Mohs surgery. We emphasize the importance of considering differential diagnoses and the need for deep biopsies to avoid diagnostic delays and to establish appropriate treatment.

Author Biographies

  • Camila Anderlini, Private University Hospital of Córdoba, Córdoba, Argentina

    Resident Physician, Dermatology Department

  • Gisel Astronave, Private University Hospital of Córdoba, Córdoba, Argentina

    Staff Physician, Dermatology Department

  • Sofía Zanitti, Private University Hospital of Córdoba, Córdoba, Argentina

    Resident Physician, Dermatology Department

  • Marco Mazzota, Private University Hospital of Córdoba, Córdoba, Argentina

    Staff Physician, Pathological Anatomy Service

  • Enrique Valente, Private University Hospital of Córdoba, Córdoba, Argentina

    Head of the Dermatology Service

References

I. Kim DW, Lee G, Lam MB, Harris E, et ál. Microcystic adnexal carcinoma of the face treated with definitive chemoradiation. A case report and review of the literature. Adv Radiat Oncol. 2019;5:301-310.

II. Yu JB, Blitzblau RC, Patel SC, Decker RH, Wilson LD. Surveillance, Epidemiology, and End Results (SEER) database analysis of microcystic adnexal carcinoma (sclerosing sweat duct carcinoma) of the skin. Am J Clin Oncol. 2010;33:125-127.

III. Leibovitch I, Huilgol SC, Selva D, Lun K, et ál. Microcystic adnexal carcinoma: treatment with Mohs micrographic surgery. J Am Acad Dermatol. 2005;52:295-300.

IV. Jfri A, Al Hawsawi K, Marghalani S, Alkhuzaie A. Microcystic adnexal carcinoma: unusual presentation. J Eur Acad Dermatol Venereol. 2016; 30: 165–167.

V. Hansen T, Kingsley M, Mallatt BD, Krishnan R. Extrafacial microcystic adnexal carcinoma: case report and review of the literature. Dermatol Surg. 2009;35:1835-1839.

VI. Gordon S, Fischer C, Martin A, Rosman IS, et ál. Microcystic adnexal carcinoma: a review of the literature. Dermatol Surg. 2017;43:1012-1016.

VII. Martorell-Calatayud C, Requena-Caballero R, Botella-Estrada S, Almenar-Medina O. et ál. Carcinoma anexial microquístico: la cirugía micrográfica de Mohs como tratamiento de elección. Actas Dermosifiliogr. 2009;100:693-699.

VIII. Hoang MP, Dresser KA, Kapur P, High WA, et ál. Microcystic adnexal carcinoma: an immunohistochemical reappraisal. Mod Pathol. 2008;21:178-185.

IX. Yadlapati S, Zito PM, Rooney JA. Mohs micrographic surgery evaluation and treatment of microcystic adnexal carcinoma. In StatPearls. Treasure Island (FL): StatPearls Publishing 2023. [Consultado febrero 2025].

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Published

2025-12-01

Issue

Section

Clinical Cases