Pioderma gangrenoso asociado a colitis ulcerosa tratado con infliximab

Resumen

Resumen:El pioderma gangrenoso es una enfermedad infrecuente, inflamatoria y destructiva que pertenece al grupo de las dermatosis neutrofílicas. Su etiología es desconocida, pero es posible que se trate de un desorden inmunológico. El
infliximab es un anticuerpo monoclonal anti-factor de necrosis tumoral alfa.
Se presentan tres  pacientes con colitis ulcerosa y pioderma gangrenoso recalcitrante que no respondieron al tratamiento convencional y fueron tratados con infliximab, con resultados favorables. El infliximab parece ser una droga efectiva y bien tolerada para el tratamiento de pioderma gangrenoso asociado a colitis ulcerosa

(Dermatol Argent 2009;15(3):191-195).

Palabras clave: anti-factor de necrosis tumoral alfa, enfermedad inflamatoria intestinal, pioderma gangrenoso, colitis ulcerosa.

Title:

Abstract: Pyoderma gangrenosum is an uncommon destructive inflammatory skin disease, which belongs to the neutrophilic diseases group. Its etiology has not been clarified but a possible immunological mechanism is suggested. Infliximab is a chimeric anti-tumor necrosis factor alpha monoclonal antibody. We shall refer to 3 patients suf  ering from ulcerative colitis and recalcitrant pyoderma gangrenosum not responsive to traditional therapies, which were treated with infliximab and showed a favourable response. Infliximab seems to be an efective and well tolerated drug for the treatment of recalcitrant pyoderma gangrenosum associated with ulcerative colitis

(Dermatol Argent 2009;15(3):191-195).

Key words: anti-tumor necrosis factor alpha, inflammatory bowel disease, infliximab, pyoderma gangrenosum, ulcerative colitis