Nasosinusal mucosal melanoma: a rare entity

Authors

  • Cinthia Zambrano Güemes Sanatorium, City of Buenos Aires, Argentina
  • Silvina González Güemes Sanatorium, City of Buenos Aires, Argentina
  • Gisella Casarotto Güemes Sanatorium, City of Buenos Aires, Argentina
  • Horacio Solarz Güemes Sanatorium, City of Buenos Aires, Argentina
  • Mariano Marini Güemes Sanatorium, City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/v8cpqb03

Keywords:

mucosal melanoma, pembrolizumab, nasosinusal mucosal melanoma

Abstract

Mucosal melanoma (MM) is a rare and very aggressive variety of melanoma, representing less than 1% of these tumors. Due to its location in areas of difficult access, diagnosis and treatment are generally more complicated.  We report a case of a 73-year-old-man with epistaxis, left nasal obstruction, proptosis, epiphora and ipsilateral diplopia for 2 months, with evidence of tumor lesion in the left nasal cavity compatible with MM. He started treatment with pembrolizumab, with a good response.

Author Biographies

  • Cinthia Zambrano, Güemes Sanatorium, City of Buenos Aires, Argentina

    Medical Doctor from the Specialist Medical Career in Dermatology, University of Buenos Aires (UBA)

  • Silvina González, Güemes Sanatorium, City of Buenos Aires, Argentina

    Physician of the Dermatology Service, Stomatology Section

  • Gisella Casarotto, Güemes Sanatorium, City of Buenos Aires, Argentina

    Staff Physician, Dermatology Service

  • Horacio Solarz, Güemes Sanatorium, City of Buenos Aires, Argentina

    Head of the Pathology Service

  • Mariano Marini, Güemes Sanatorium, City of Buenos Aires, Argentina

    Head of the Dermatology Service

References

I. Sergi MC, Filoni E, Triggiano G, Cazzato G, et al. Mucosal melanoma: epidemiology, clinical features and treatment. Curr Oncol Rep. 2023;25:1247-1258.

II. Olla D, Neumeister MW. Mucosal melanoma. Clin Plast Surg. 2021; 48:707-711.

III. Spencer KR, Mehnert JM. Mucosal melanoma: epidemiology, biology and treatment. Cancer Treat Res. 2016;167:295-320.

IV. Bachar G, Loh KS, O'Sullivan B, Goldstein D, et al. Mucosal melanomas of the head and neck: experience of the Princess Margaret Hospital. Head Neck. 2008;30:1325-1331.

V. Beltrán LC, Thompson P, Alvarenga R. Melanoma nasosinusal en paciente con síndrome de Rendu-Osler-Weber: reporte de un caso. Revista Faso. 2020;2:75-78.

VI. Romo-Magdaleno JA, Busto-Ruano JP, Reyes-Ortega LM. Melanoma de la mucosa nasal. An Orl Mex. 2020;65:191-198.

VII. Moctezuma-Bravo G, Díaz de León-Medina R, Rodríguez-Quilantán F, Salgado-Nevárez M, et al. Melanoma nasomaxilar: revisión de la literatura y reporte de un caso. Gac Mex Oncol. 2016;15:181-186.

VIII. Kuan EC, Wang EW, Adappa ND, Beswick DM, et al. International consensus statement on allergy and rhinology: sinonasal tumors. Int Forum Allergy Rhinol. 2024;14:149-608.

IX. Nakamura Y, Namikawa K, Yoshikawa S, Kiniwa Y, et al. Anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy in unresectable or metastatic mucosal melanoma: a retrospective, multicenter study of 329 Japanese cases (JMAC study). ESMO Open. 2021;6:100325.

Downloads

Published

2026-04-28

Issue

Vol. 32 No. 1 (2026): January-april

Section

Clinical Cases

License

Copyright (c) 2026 on behalf of the authors. Reproduction rights: Argentine Dermatology

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

El/los autor/es tranfieren todos los derechos de autor del manuscrito arriba mencionado a Dermatología Argentina en el caso de que el trabajo sea publicado. El/los autor/es declaran que el artículo es original, que no infringe ningún derecho de propiedad intelectual u otros derechos de terceros, que no se encuentra bajo consideración de otra revista y que no ha sido previamente publicado.

 

Le solicitamos haga click aquí para imprimir, firmar y enviar por correo postal la transferencia de los derechos de autor