Disseminated histoplasmosis with mucocutaneous involvement in an immunocompetent patient

Authors

  • Candela Pagirys Austral University Hospital, Buenos Aires Province, Argentina
  • Berenice Fouces Austral University Hospital, Province of Buenos Aires, Argentina
  • Javier Anaya Austral University Hospital, Buenos Aires Province, Argentina
  • Corina Busso Austral University Hospital, Province of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v31i3.2971

Keywords:

histoplasma capsulatum, disseminated histoplasmosis, systemic mycosis

Abstract

Histoplasmosis is a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum. Primary infection is usually asymptomatic; however, disseminated disease may develop in people with compromised cellular immunity. We describe the case of a 79-year-old immunocompetent patient who developed disseminated histoplasmosis with prominent mucocutaneous involvement. We highlight the importance of clinical suspicion due to the marked lesional polymorphism of this entity.

Author Biographies

  • Candela Pagirys, Austral University Hospital, Buenos Aires Province, Argentina

    Resident Physician, Dermatology Department

  • Berenice Fouces, Austral University Hospital, Province of Buenos Aires, Argentina

    Staff Physician, Chief Resident, Dermatology Service

  • Javier Anaya, Austral University Hospital, Buenos Aires Province, Argentina

    Staff Physician, Pathological Anatomy Service

  • Corina Busso, Austral University Hospital, Province of Buenos Aires, Argentina

    Dermatologist, Head of the Dermatology Service

References

I. Gómez-Santana LV, Torre AC, Hernández BA, Volonteri VI, et ál. Mucocutaneous manifestations of infection by Histoplasma capsulatum in HIV-negative immunosuppressed patients. Actas Dermosifiliogr. 2018;109: e27-e32.

II. Francini B, Cánepa MC, Lamonica C, Capece P, et ál. Histoplasmosis diseminada. Una infección oportunista en pacientes con infección por VIH. Experiencia en el Hospital Nacional Prof. A. Posadas, 2011-2017. Rev Chil Infectol. 2018;35:671-679.

III. Chang P, Rodas C. Skin lesions in histoplasmosis. Clinics in Dermatology. 2012;30: 592-598.

IV. Negroni R. Manifestaciones cutaneomucosas de la histoplasmosis diseminada (histoplasmosis clásica o Histoplasma capsulatum). Dermatol Argent. 2008;14:104-112.

V. Hati A, Sen S, Mallick S, Das S. Disseminated histoplasmosis with oral and cutaneous manifestations in an immunocompetent patient. Indian J Dermatol. 2020; 65: 552.

VI. Babariya H, Gaidhane SA, Acharya S, Kumar S. Coccidioidomycosis and histoplasmosis in Iimmunocompetent individuals. A comprehensive review of clinical features, diagnosis, and management. Cureus. 2024;16:e68375.

VII. Galgiani JN, Kauffman CA. Coccidioidomycosis and histoplasmosis in immunocompetent persons. N Engl J Med. 2024;390:536-47.

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Published

2025-12-01

Issue

Vol. 31 No. 3 (2025): September-December

Section

Clinical Cases

License

Copyright (c) 2025 on behalf of the authors. Reproduction rights: Argentine Society of Dermatology

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