Why do we age? Hallmarks of aging

Authors

  • Natasha Paola Castillo Velásquez Dr. Francisco J. Muñiz Infectious Diseases Hospital, Autonomous City of Buenos Aires, Argentina
  • Julieta Soledad Fischer Dr. Francisco J. Muñiz Infectious Diseases Hospital, Autonomous City of Buenos Aires, Argentina
  • Mauro Coringrato Dr. Francisco J. Muñiz Infectious Diseases Hospital, Autonomous City of Buenos Aires, Argentina

DOI:

https://doi.org/10.47196/da.v30i2.2507

Keywords:

aging, longevity, inflammation, senescence

Abstract

Aging is a complex biological process characterized by cumulative and progressive changes in organisms over time. The hallmarks of aging represent the key features and underlying mechanisms contributing to this phenomenon. Understanding these hallmarks is essential for addressing the challenges associated with aging and developing effective therapeutic strategies.

Author Biographies

  • Natasha Paola Castillo Velásquez, Dr. Francisco J. Muñiz Infectious Diseases Hospital, Autonomous City of Buenos Aires, Argentina

    Concurrent Physician, Dermatology Unit

  • Julieta Soledad Fischer, Dr. Francisco J. Muñiz Infectious Diseases Hospital, Autonomous City of Buenos Aires, Argentina

    Staff Physician, Dermatology Unit

  • Mauro Coringrato, Dr. Francisco J. Muñiz Infectious Diseases Hospital, Autonomous City of Buenos Aires, Argentina

    Staff Physician, Dermatology Unit

References

I. López-Otín C, Blasco MA, Partridge L, Serrano M, et ál. Hallmarks of aging. An expanding universe. Cell 2023;186:243-278.

II. Dattani S, Rodés-Guirao L, Ritchie H, Ortiz-Ospina E, et ál. Life expectancy 2023. Disponible en: https://ourworldindata.org/life-expectancy> [Consultado mayo 2024].

III. Rueda-Hernández LV. Esperanza de vida e inicio de la etapa de adulto mayor. Salud Uninorte 2022;38:5-20.

IV. López-Otín C, Blasco MA, Partridge L, Serrano M, et ál. The hallmarks of aging. Cell. 2023;153:1194-1217.

V. Fakouri NB, Hou Y, Demarest TG, Christiansen LS, et ál. Toward understanding genomic instability, mitochondrial dysfunction and aging. The FEBS Journal. 2019;286:1058-1073.

VI. Sen P, Shah PP, Nativio R, Berger SL. Epigenetic mechanisms of longevity and aging. Cell. 2016;166:822-839.

VII. Kaushik S, Tasset I, Arias E, Pampliega O, et ál. Autophagy and the hallmarks of aging. Ageing Res Rev. 2021;72:101468.

VIII. Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochondrial dysfunction in cell senescence and aging. J Clin Invest. 2022;132:e158447.

IX. Birch J, Gil J. Senescence and the SASP: many therapeutic avenues. Genes Dev. 2020;34:1565-1576.

X. Liu S, Zhou J, Zhang X, Liu Y, et ál. Strategies to optimize adult stem cell therapy for tissue regeneration. Int J Mol Sci. 2016;17:982.

XI. Zeitz MJ, Smyth JW. Gap junctions and ageing. Subcell Biochem. 2023;102:113-137.

XII. Biagi E, Franceschi C, Rampelli S, Severgnini M, et ál. Gut microbiota and extreme longevity. Curr Biol. 2016;26:1480-5.

XIII. O'Toole PW, Jeffery IB. Gut microbiota and aging. Science. 2015;350:1214-1215.

Downloads

Published

2024-05-16

Issue

Section

Continuing Medical Education