Cutaneous T-cell lymphoma and multiple myeloma in the same patient
Keywords:
cutaneous T-cell lymphoma, myeloma, B-cell malignancy, Sezary syndrome, mycosis fungoidesAbstract
The coexistence in the same patient of T-cell cutaneous lymphoma and a B-cell malignancy such as a multiple myeloma is unusual. We present a 76-year-old man with erythroderma, lymphadenopathy and circulating Sézary cells, diagnosed as Sézary Syndrome. At the same time, a concomitant high-risk IgG kappa multiple myeloma was diagnosed. The origin of this association is not defined, which could correspond to the malignant transformation of a cell with T or B differentiation capacity, or to the immunoregulatory alterations that the initial neoplasia could generate on the development of the second. It is important to be aware of this rare association for the correct diagnosis and appropriate treatment of both diseases.
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