Anticonvulsant hypersensitivity syndrome (DRESS syndrome): report of 4 cases

Autores/as

  • Sabrina Meik
  • Mariana Arias
  • Mariana Arias
  • Laura Fernández Mego
  • Laura Fernández Mego
  • María Carolina López Santoro
  • María Carolina López Santoro
  • Alejandra Abeldaño
  • Alejandra Abeldaño
  • Graciela Pellerano
  • Graciela Pellerano

Resumen

Abstract

Anticonvulsant hypersensitivity syndrome is a rare and potentially fatal reaction characterized by fever, skin rash and internal organ envolvement. Phenytoin, phenobarbital and carbamazepine are
the most frequent aromatic anticonvulsivant drugs causing the reaction.
We report 4 adult patients, 2 males and 2 females, between 20 and 42 years old with clinical, laboratorial and histopathological findings consistent with anticonvulsant hypersensitivity syndrome started 4 and 8 weeks after the administration of the drug. The causative drugs were
phenytoin, carbamazepine and the association of valproic acid and lamotrigine

(Dermatol Argent 2010;16(4):272-277).

Keywords: DRESS (Drug Rash with Eosinophilia and Systemic Symptoms), Anticonvulsant hypersensitivity syndrome.

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Publicado

2013-03-25

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